BRD9 functions as a methylarginine reader to regulate AKT-EZH2 signaling

Sasha Yin, Charles Brobbey, Lauren E. Ball, Tianmin Fu, Daniel J. Sprague, Wenjian Gan

Science Advances, 2025

The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation

Raymundo Nuñez, Paul F. W. Sidlowski, Erica A. Steen, Sarah L. Wynia-Smith, Daniel J. Sprague, Robert F. Keyes, Brian C. Smith

ACS Chemical Biology, 2024 Nov 18

Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types

Rachel A. Jones Lipinski, Jennifer S. Stancill, Raymundo Nunez, Sarah L. Wynia-Smith, Daniel J. Sprague, Joshua A. Nord, Amir Bird, John A. Corbett, Brian C. Smith

American Journal of Physiology -- Regulatory, Integrative and Comparative Physiology, 2024 May 29

Target-based discovery of a broad spectrum flukicide

Daniel J. Sprague, Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M. Rohr, Evgeny G. Chulkov, Emery Smith, Louis Scampavia, Timothy P. Spicer, Simone Haeberlein, Jonathan S. Marchant

Nature Structural and Molecular Biology, 2024 May 7

TRP drop, TRP drop: a steady patter of anti-schistosomal target illumination

Daniel J. Sprague#, Claudia M. Rohr#, Jonathan S. Marchant

Frontiers in Parasitology, 2024 Feb 12

The anthelmintic meclonazepam activates a schistosome transient receptor potential channel

Sang-Kyu Park#, Daniel J. Sprague#, Claudia M. Rohr, Evgeny G. Chulkov, Ian Petrow, Sushil Kumar, Jonathan S. Marchant

Journal of Biological Chemistry, 2024 Jan

The anthelmintic activity of praziquantel analogs correlates with different structure-activity relationships at TRPMPZQ orthologs

Daniel J. Sprague*, Marc Kaethner, Sang-Kyu Park, Claudia M. Rohr, Jade L. Harris, David Maillard, Thomas Spangenberg, Britta Lundstrom-Stadelmann, Jonathan S. Marchant*

ACS Medicinal Chemistry Letters, 2023 Oct 25

Mu-Opioid Receptor Selective Superagonists Produce Prolonged Respiratory Depression

Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy

iSCIENCE, 2023 Jun 13

Molecular and cellular basis of praziquantel action in the cardiovascular system

Nawal A. Yahya, Janelle K. Lanham, Daniel J. Sprague, Oleg Palygin, John D. McCorvy, Jonathan S. Marchant

American Journal of Physiology -- Cell Physiology, 2023 Feb 1

Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity

Claudia M. Rohr, Daniel J. Sprague, Sang-Kyu Park, Nicholas J. Malcolm, Jonathan S. Marchant

Proceedings of the National Academy of Sciences, 2023 Jan 3

Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin

Mahmoud AbuEid, Robert F. Keyes, Donna McAllister, Francis Peterson, Ishaque Pulikkal Kadamberi, Daniel J. Sprague, Pradeep Chaluvally-Raghavan, Brian C. Smith, Michael B. Dwinell

iSCIENCE, 2022 Dec 22

Identification of a dihydropyridine scaffold that blocks ryanodine receptors

Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan, Thiago Arzua, Talia Frolkis, Daniel J. Sprague, Xiaowen Bai, Razvan L. Cornea, Timothy F. Walseth, Jonathan S. Marchant

iSCIENCE, 2022 Jan 22

Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12

Daniel J. Sprague, Anthony E. Getschman, Tyler G. Fenske, Brian F. Volkman, Brian C. Smith

ACS Medicinal Chemistry Letters, 2021 Oct 18

Development of activity-based probes for the protein deacylase Sirt1

Christopher J. Goetz, Daniel J. Sprague, Brian C. Smith

Bioorganic Chemistry, 2020 Aug 26

Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites

Michael D. Olp, Daniel J. Sprague, Christopher J. Goetz, Stefan G. Kathman, Sarah L. Wynia-Smith, Shifali Shishodia, Steven B. Summers, Ziyang Xu, Alexander V. Statsyuk, Brian C. Smith

ACS Chemical Biology, 2020 Mar 9

Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator

Daniel J. Sprague, Jeffrey N. Johnston

Organic Letters, 2020 Oct 15

Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution

Daniel J. Sprague, Anand Singh, Jeffrey N. Johnston

Chemical Science, 2018 Jan 31

Count on It! Accurately Measured Respiratory Rate Is Associated with Lung Function and Clinical Severity in Children with Acute Asthma Exacerbations

Donald H. Arnold, Cody H. Penrod, Daniel J. Sprague, Tina V. Hartert

Journal of Pediatrics, 2016 Aug

Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis

Daniel J. Sprague, Benjamin N. Nugent, Ryan A. Yoder, Brandon A. Vara, Jeffrey N. Johnston

Organic Letters, 2015 Jan 31

Enantio- and periselective nitroalkene Diels–Alder reaction

Maurice J. Narcis, Daniel J. Sprague, Burjor Captain, Norito Takenaka

Organic & Biomolecular Chemistry, 2012 Dec 14